Development of the CAM Tumour Model and HF-US Imaging Methods to Assess Response to Anti-Angiogenic Agents | Terry Fox Research Institute Seminar

To facilitate the use of the CAM PDX model for hyperpersonalized treatment planning, a rapid evaluation of the response of 50-100 CAM PDXs would be required per patient over time. Micro ultrasound (µUS) could play an important role in this evaluation by providing high resolution tumor volume and flow-based measurements without contrast agent injection.

Although recent work has shown that µUS power Doppler performs poorly in detecting CAM tumor microvessels, a more robust speckle variance approach is being developed for CAM tumor flow imaging. This work outlines the HF-US parameters and image acquisition protocol utilized for this purpose.

Please find the slides here.